Article: UNDERSTANDING DHATUKSHAYA THROUGH THE LENS OF PRAMEHA: A COMPREHENSIVE REVIEW

Article Category: Review articles

DOI: 10.7897/2277-4343.16273

Pages: 209-212

Author: Shilpa KG *, Manjunatha Adiga, Amritha E Pady

Abstract: Dhatukshaya, or the depletion of bodily tissues, is a fundamental concept in ayurveda that highlights the progressive degeneration of the seven dhatus. Prameha progresses through stages linked to the tridosha: kapha in early stages, pitta in intermediate stages, and vata in advanced stages, exacerbating degeneration due to dhatu shitilata (tissue laxity) and obstruction in the srotas. The pathogenesis of prameha involves derangement of doshas, subsequent impairment of dhatwagni, and metabolic disturbances in the dhatus, which in turn disrupt normal carbohydrate, fat, and protein metabolism. These further damages the tissues and impacts the mutravaha srotas (urinary system). Prameha progressively affects multiple dhatus (tissues) including rasa, meda, and majja, leading to symptoms such as polyuria, polydipsia, polyphagia, fatigue, dryness, and neuropathy. Tissue depletion disrupts nourishment, fluid balance, and energy reserves, resulting in systemic complications over time. Diabetes Mellitus has become a major global health concern, causing extensive numerous cellular damages in different organs at various stages of the disease. Diabetes contributes or accelerates the process of degeneration by chronic hyperglycemia, oxidative stress, advanced glycation end products (AGEs), inflammation and immune dysregulation.

Keyword: Dhatukshaya, Prameha, Degeneration, Diabetes.