Article: A REVIEW ON MURRAYA KOENIGII AND MAHANIMBINE ACTIVITY AGAINST OBESITY

Article Category: Review articles

DOI: 10.7897/2277-4343.16279

Pages: 242-246

Author: Shikha Kumari *

Abstract: Murraya koenigii, commonly known as curry leaf, is a medicinal plant widely recognized for its diverse pharmacological properties. Among its bioactive constituents, mahanimbine, a carbazole alkaloid has garnered significant attention for its potential anti-obesity effects. Obesity, a global health concern, is associated with metabolic disorders, including diabetes, cardiovascular diseases, and inflammation. Recent studies highlight mahanimbine's ability to regulate lipid metabolism, suppress adipogenesis, and enhance energy expenditure, making it a promising candidate for obesity management. Additionally, Murraya koenigii extracts exhibit antioxidant, anti-inflammatory, and hypolipidemic properties, further contributing to metabolic health. This review provides a comprehensive analysis of Murraya koenigii, with a specific focus on mahanimbine's molecular mechanisms in combating obesity. It explores its role in modulating key signaling pathways, including AMPK activation, adipocyte differentiation, and thermogenesis. Furthermore, we discuss preclinical and in vivo findings that support mahanimbine’s efficacy as a natural anti-obesity agent. While the therapeutic potential of Murraya koenigii and its alkaloids is promising, challenges such as bioavailability, dosage optimization, and clinical validation remain crucial areas for future research. Understanding these aspects may pave the way for the development of novel nutraceuticals or pharmacological interventions targeting obesity and metabolic disorders. This review aims to bridge the gap between traditional knowledge and modern scientific advancements, emphasizing the need for further studies to establish the clinical relevance of Murraya koenigii -derived compounds in obesity management.

Keyword: Murraya koenigii, Mahanimbine, Obesity, Lipid metabolism and Adipogenesis