Article: IN-VITRO EVALUATION OF THE ANTIULCER POTENTIAL OF BAVANA KADUKKAI MATHIRAI

Article Category: Original Research articles

DOI: 10.7897/2277-4343.16280

Pages: 247-250

Author: Manivannan Periyasamy *, Suresh Ramasamy, Mahalakshmi V

Abstract: The Siddha system of medicine, widely practised in Southern India, includes numerous formulations for treating various ailments. Bavana Kadukkai Mathirai (BVK) is a traditional Siddha formulation for managing Gunmam (Peptic ulcer disease). Peptic ulcers occur due to an imbalance between aggressive factors like gastric acid, pepsin, and H. pylori and defensive factors such as mucin, prostaglandins, and bicarbonate. This study evaluates the acid- neutralizing capacity of BVK using an in-vitro method. The formulation was prepared using key herbal ingredients, including Terminalia chebula, Zingiber officinale, Piper longum, and Trachyspermum ammi, which are known for their gastroprotective properties. The results showed a concentration-dependent increase in acid-neutralizing activity, with BVK at 250 mg/mL exhibiting an acid-neutralizing capacity (ANC) of 4.6, while 500 mg/mL showed an ANC of 11.3, compared to the standard antacid (Aluminium Hydroxide + Magnesium Hydroxide) at 11.90. These findings suggest that BVK exhibits significant acid-neutralizing efficacy comparable to conventional antacids, particularly at higher concentrations. Previous studies on the individual ingredients of BVK support its gastroprotective and antiulcer properties, reinforcing its traditional use in treating gastrointestinal disorders. Further, in-vivo studies and clinical trials are needed to explore its pharmacological mechanisms, efficacy, and safety profile for potential therapeutic applications.

Keyword: Siddha Medicine, Kaya Karpam, Bavana kadukkai (BVK), Antiulcer, Acid Neutralizing Capacity.