Article: EFFICACY OF PATHADI KWATHA AND KANCHNARADI KWATHA WITH AROGYAVARDHINI VATI IN THE MANAGEMENT OF PCOS: AN OPEN-LABELLED, RANDOMISED COMPARATIVE CLINICAL TRIAL

Article Category: Original Research articles

DOI: 10.7897/2277-4343.173100

Pages: 65-75

Author: Poonam Choudhary *, Prachi Gupta

Abstract: Background: Polycystic ovarian syndrome (PCOS) is a heterogenous and multifactorial endocrine metabolic disorder that causes women to have a variety of symptoms. Pathadi Kwatha, indicated in Vata Kaphaja Artavadushti, and Kanchnaradi Kwatha, indicated in Granthi Chikitsa, are used here to treat PCOS. Considering PCOS as Dhatwagni mandyajanya Beejgranthi Vikara, Arogyavardhini Vati was added to both groups. Material and Methods: A total of 100 patients diagnosed with PCOS, confirmed by hormonal analysis and ultrasonography, were selected for a randomised clinical trial. Of these, 50 patients were registered in each of two groups, i.e., group A and group B. Group A received Pathadi Kwatha and Arogyavardhini Vati, and group B received Kanchnaradi Kwatha and Arogyavardhini Vati. Kwatha was given at a dose of 80 ml in Apana Kala twice daily, and Arogyavardhini Vati, 2 tablets (250 mg each), morning and evening for 3 months. Results: In Group A, moderate improvement was observed in 72% of patients, whereas in Group B, it was observed in 46%. Mild improvement was found in 18% and 40% of patients in Groups A and B, respectively. Conclusion: The trial drugs Pathadi Kwatha and Arogyavardhini Vati reduce overall symptoms by enhancing Agni at the cellular level, and Kanchanaradi Kwatha and Arogyavardhini Vati have proven more effective in limiting cyst formation in the ovary. Hence, it can be concluded that both Group A and Group B are effective drugs for managing PCOS; however, Pathadi Kwatha and Arogyavardhini Vati showed a comparatively better effect than Kanchanaradi Kwatha and Arogyavardhini Vati in PCOS (Dhatvagnimandya Janya Beejagranthi Vikara).

Keyword: Arogyavardhini Vati, Dhatwagnimandyajanya Beejgranthi Vikara Hyperandrogenism, Kanchnaradi Kwatha, Pathadi Kwatha, PCOS