IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.096171 ANALYTICAL STANDARDIZATION OF MANDURA BHASMA Kishore Kumar H * Sridurga CH Venkata Subbaiah K 11 -0001 47 52 Background:Rasa Shastra is an independent branch of Ayurvedic medicine, which deals with preparation of the drugs of metals and minerals with higher efficacy in lower dose and good palatability. Mandura Bhasma is an important formulation mentioned in Rasa Shastra texts obtained from the incineration of Raw Mandura. The pharmaceutical procedures involved in the preparation of Mandura Bhasma are Shodhana, Bhavana and Marana.__ampersandsignnbsp;Objective:To assess the safety and to understand about the identity, form, particle size and surface morphology of the Mandura Bhasma.__ampersandsignnbsp;Materials and Methods:Mandura bhasma was subjected to analysis through various techniques like__ampersandsignnbsp;X-raydiffraction__ampersandsignnbsp;(XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDS), Particle size analysis (PSA), Zeta Potential (ZP), UV-Spectroscopy and Fourier transform Infra-Red spectroscopy (FTIR).__ampersandsignnbsp;Results and__ampersandsignnbsp;Conclusion:XRD of Mandura Bhasma showed__ampersandsignnbsp;major peaks of Fe2O3__ampersandsignnbsp;(Iron oxide) and a minor peak K2SO4(Potassium Sulphate). SEM micrographs showed irregular distribution of more or less Rhombohedral particles. EDS analysis confirmed the significant presence of elements viz.__ampersandsignnbsp;__ampersandsignnbsp;Fe-38.09%, O- 29.38%, Ca- 0.40%, and K-0.52%. Particle size was found to be 3.2 nm with Zeta Potential of -32.7 mV. UV- Spectrum of Mandura Bhasma showed maximum absorption at 300 nm. FTIR test showed 26 peaks between the wavelength__ampersandsignnbsp;3696.60cm-1to 632.67cm-1. This shows that Raw Mandura has been completely transformed into compound form (Bhasma) without any traces of free elemental form. Mandura Bhasma Analytical Tests Safety Toxicity.