IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.100110 ROLE OF VIRECHANA KARMA IN DIABETES MELLITUS TYPE 2: A CLINICAL TRIAL Tiwari Swati * Gupta Sanjay Srivastava Kumar Alok 11 -0001 40 43 Diabetes__ampersandsignnbsp;is a major public health problem that is approaching epidemic proportions globally.__ampersandsignnbsp;It is the most common endocrine disorder with an increasing global prevalence and incidence.__ampersandsignnbsp;Type 2 diabetes is associated with a ten-year-shorter life expectancy.Diabetes Mellitus__ampersandsignnbsp;is aggravated by and associated with metabolic complications that can subsequently lead to premature death.__ampersandsignnbsp;The available drug therapy has good effects on levels of blood sugar but it has many side effects and also its dose increases with time, while__ampersandsignnbsp;Ayurvedanot only gives efficient results on high blood sugar but also does not have any side effects. On behalf of blood sugar profile and BMI, the evaluation of Virechana__ampersandsignnbsp;Karma(medicated purgation therapy)__ampersandsignnbsp;was done in comparison to modern oral hypoglycemic and well-practiced drug Metformin. Total 40 patients of newly diagnosed cases of Diabetes Mellitus were taken and divided into two groups. As Trial group, 20 patients were given 2 sittings of Virechana Karma with study period of 60 days while in Control Group 20 patients were given tablet Metformin 500 mg O.D. for 60 days.__ampersandsignnbsp;Virechanais found to be more effective than Metformin.75.86% reduction was found in Blood sugar F, 77.59% reduction in Blood sugar PP, 20.00% reduction in HbA1C and 65.00% reduction in BMI was found in__ampersandsignnbsp;Virechanagroup. So,__ampersandsignnbsp;Virechanakarmahas highly significant results in reducing blood sugar levels, HbA1c and BMI along with better follow up results. Diabetes Mellitus Type 2 Endocrine Madhumeha Ayurveda Virechana Karma