IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.100112 EFFICACY OF TUKHM-E-SUDDAB (RUTA GRAVEOLENS) IN THE MANAGEMENT OF__ampersandsignnbsp;SALABAT-E-NABZ (ATHEROSCLEROSIS): A RANDOMIZED, SINGLE BLIND, PLACEBO CONTROLLED CLINICAL TRIAL Iram Naaz Mohd Shahid * Tanzeel Ahmad 11 -0001 49 54 Aim:Presently, atherosclerosis is one of the prime threats worldwide as only in India CVD causes 37 million deaths annually raised by 59% from 23.2 million in last two decades which is higher than the global average. The standard treatment available for it had appalling side effects in long terms. This condition can be correlated to__ampersandsignnbsp;Salabat-e-Nabzin Unani system of medicine, treated since centuries through numerous compounds and single drugs. Tukhm Suddab(Ruta graveolens) is one of the single drugs which is indicated for the same, but has not been evaluated on the scientific parameters. Thus, a randomised, single blind placebo controlled clinical study was designed with an objective to determine the efficacy and safety of Tukhm Suddab(Ruta graveolens) in the management of__ampersandsignnbsp;Salabat-e-Nabz(atherosclerosis).__ampersandsignnbsp;Methods: The present clinical trial was a single blinded, randomized, placebo control study__ampersandsignnbsp;conducted at NIUM hospital, Bangalore, on__ampersandsignnbsp;sample size of 40 patients. Test group was treated with three capsules twice a day (each capsule contain 1 gm powder of test drug) and control group was treated with same dose filled with wheat flour for consecutive 90 days. Objective parameters and BP were assessed at every 15thday from baseline to 90thday of treatment in each group respectively. Result: Significant results were observed in right ABI (p __ampersandsignlt;0.002), left ABI (p __ampersandsignlt;0.01) and LDL level (p __ampersandsignlt;0.05), at 90thday from baseline. While no significant result were observed in ASI and other objective parameters. Conclusion:This trial validates the effectiveness and safety of__ampersandsignnbsp;Tukhm Suddab(Ruta graveolens)in the treatment of__ampersandsignnbsp;Salabat-e-Nabz(atherosclerosis). Salabat-e-Nabz Atherosclerosis Ankle Brachial Index. Arterial Stiffness Index LDL Tukhm-e-Suddab Unani CTRI