IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.100122 COMPARATIVE CLINICAL TRIAL OF BHARANGIMOOLA ARKA AND SALBUTAMOL NEBULIZATION IN TAMAKA SHWASA (ACUTE EXACERBATION OF BRONCHIAL ASTHMA): A CASE SERIES STUDY Manjunatha Adiga * Prasanna N Rao Priyanka B V Mallika K J 11 -0001 90 94 Abstract Tamaka Shwasa__ampersandsignnbsp;(Bronchial asthma)__ampersandsignnbsp;is a disease occurring due to involvement of Vata and Kapha which presents in two forms __ampersandsignndash; Vaigika (Acute exacerbated) or Avaigika (under control).__ampersandsignnbsp;An emergency management is required during acute exacerbation. Pilot study has proved a statistically highly significant difference in symptoms like breathlessness (Z = -4.820, p= 0.000) after treatment with Nebulization of Bharangimoola Arka (5ml administered 8th hourly for 3 times) and also FVC% and FEV1% have improved significantly with a t value equal to -5.857 and -5.090 respectively with p__ampersandsignlt;0.05. Hence__ampersandsignnbsp;an__ampersandsignnbsp;effort is put forth to compare Bharangimoola Arka with standard drug salbutamol Nebulization in controlling the acute__ampersandsignnbsp;exacerbation state in six episodes of administration.The main aim of the study was to compare the efficacy of Bharangimoola Arka Nebulization with standard drug Salbutamol in reducing the symptoms of Vegavasta (Acute exacerbated) of Tamaka Shwasa (Acute exacerbation of Bronchial Asthma).__ampersandsignnbsp;It was an open label, single center, prospective, double arm clinical study conducted in 100 patients of__ampersandsignnbsp;acute exacerbation of Bronchial Asthma.__ampersandsignnbsp;The patients falling under the inclusion criteria were taken for the study and pre and post spirometry was done to evaluate the broncho dilation effect. The patients were hospitalized for 2 days, and nebulization was done 8th hourly with a fixed dose of 5 ml of Bharangimoola Arka and 2.5 ml of Salbutamol sulphate in two groups. Before and after each episode of nebulization, Peak Expiratory Flow Test was done.__ampersandsignnbsp;This study provides evidence for the significant effect of 5 ml of Bharangimoola Arka in reducing the symptoms like Breathlessness, Wheeze and Cough__ampersandsignnbsp;__ampersandsignnbsp;in Acute exacerbation of Bronchial asthma which is on par with the standard drug Salbutamol Sulphate - 2.5ml when administered six doses 8th hourly without inducing tremors. Keywords Arka Ayurveda Bharangimoola Bronchial asthma Salbutamol Clerodendrum serratum (Linn.) Nebulization Tamaka Shwasa. References