IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.100234 CLINICAL EVALUATION OF EFFICACY AND SAFETY OF TAB HF-B1 IN OSTEOPENIA AND OSTEOPOROSIS: AN OBSERVATIONAL STUDY Omkar Kulkarni * Veena Deo and Bharatbhushan Shrikhande 11 -0001 41 46 Osteopenia and Osteoporosis has been a very common problem faced globally on account of faulty lifestyle, diet and environmental reasons. It increases chances of debility due to frequent fractures and inflammatory conditions. Conventional medications contain synthetic calcium supplementation which mostly remains a temporary solution with potential gastrointestinal and cardiovascular side effects. This calls for the need to explore effective treatment modalities. Herbal medicines have proved efficacious in the treatment of bone disorders since ancient time. Herewith we studied Tab HF-B1, a herbo-mineral Ayurvedic formulation for the treatment of osteopenia and osteoporosis in an open label, observational clinical study. We observed that there was decrease in mean ranks of symptoms such as bone pain and joint pain. There was a significant increase in T-Score and BQI. No adverse events were recorded suggesting a good compliance and tolerability. Thus Tab HF-B1 was found to be safe and effective in the management of patients with Osteopenia and Osteoporosis.__ampersandsignnbsp; Polyherbal Formulation Natural Calcium Osteoporosis Calcium Supplementation.