IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.100247 EVALUATION OF ANALGESIC ACTIVITY OF__ampersandsignnbsp;BULBOPHYLLUM NEILGHERRENSE__ampersandsignnbsp;WIGHT (ORCHIDACEAE) Rahman Zubair Fariba Mahnaz Hossain Mahbub Nuzum Bashar ABM Anwarul Rahmatullah Mohammed * 11 -0001 106 108 Background:__ampersandsignnbsp;Bulbophyllum neilgherrense__ampersandsignnbsp;is considered a medicinal orchid in Bangladesh and south India, the pseudobulb being used to treat leucoderma. However, the plant has not been studied scientifically to any large extent. It was the objective of the present study to evaluate the analgesic activity of methanol extract of the whole plant. Materials and Methods: Analgesic activity was studied by the acetic acid-induced writhing method in Swiss albino mice. Results: Methanolic extract of__ampersandsignnbsp;B. neilgherrense__ampersandsignnbsp;(MEBN), when administered to mice in acetic acid-induced writhing tests dose-dependently reduced the number of writhings (constrictions). At doses of 50, 100, 200 and 400 mg per kg body weight MEBN reduced the number of writhings, respectively, by 23.5, 41.2, 50.0 and 67.6%. By comparison, a standard analgesic drug, aspirin reduced the number of writhings by 41.2 and 67.6%, respectively at doses of 200 and 400 mg per kg body weight.__ampersandsignnbsp;__ampersandsignnbsp;Conclusion: The results indicate that__ampersandsignnbsp;B. neilgherrense__ampersandsignnbsp;methanolic extract can effectively reduce pain in a manner comparable to that of aspirin. The results further suggest that the plant may prove to be a good source of pain-alleviating compound(s). Bulbophyllum neilgherrense; analgesic; writhing; pain; Orchidaceae.