IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.100370 EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF TRAYODASHANG GUGGULU: AN AYURVEDIC FORMULATION IN COMPARISON WITH ALLOPATHIC DRUGS M Sahiti BM Gurupadayya * and TK Dinesh 11 -0001 92 96 The main objective was to assess the in vitro anti inflammatory activity of the Ayurvedic formulation Trayodashang Guggulu in comparison to commercially available allopathic drugs. Anti inflammatory activity was estimated by inhibition of protein denaturation method, which in turn was preceded by adapting two different types of proteins which are egg albumin and bovine serum albumin. These were incubated along with actives and incubated in carefully controlled experimental conditions. The Ayurvedic formulation that is prepared prior was compared with six commercially available allopathic standards. The study results showed inhibition of protein according to the concentration of the active used. The Ayurvedic formulation showed prominent anti inflammatory activity better than the allopathic drugs at all concentrations that are selected between 200 to 1000__ampersandsignmicro;g/ml except when compared to Diclofenac. This study showed that the Ayurvedic combination formulation showed good anti inflammatory properties when tested for extent of protein denaturation. But the effect due to each of its constituents should be evaluated further. Anti inflammatory Trayodashang Guggulu Allopathic drugs Protein denaturation.