IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.1006129 EVALUATION OF CLINICAL EFFICACY AND SAFETY OF STIFAIN TABLET IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS (AMAVATA) Nimish Vador * Bhavesh Vador Charmi Gor Manali Aalim 11 -0001 78 84 Abstract Rheumatoid arthritis (RA) is an inflammatory arthritis that affects nearly 1% of the world__ampersandsignrsquo;s adults and is one of the most distressing irreversible arthritis which runs a chronic course with a very poor response to medicines. Ayurveda offers large number of single and poly herbal or herbo-mineral drugs for the management of Rheumatoid arthritis (Amavata) and some of these potent drugs were selected and Stifain tablet formulated. The present trial was carried out on the cases of Rheumatoid arthritis who satisfied the diagnostic and inclusion criteria. Detailed medical history to find out the causative factors like diet and lifestyle and status of disease was recorded and examination of affected joints was done. Patients willing to participate were given Stifain tablets in the dose of one tablet (500 mg) each thrice daily with lukewarm water after meal for the duration of two months with weekly follow-up. The primary end points were assessed on basis of improvement in sign and symptoms, Disease Activity score in 28 joints (DAS-28) and Disability index (The Indian Health Assessment Questionnaire). Safety assessment was hepatic function (SGPT and alkaline phosphatase (ALP) and renal function (B. urea and S. creatinine) tests. The finding of the present study suggest that Stifain tablets can be safely used as a single drug therapy in the management of mild to moderate cases of rheumatoid arthritis. Keywords Rheumatoid arthritis efficacy and safety Stifain tablet References