IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House DOI: 10.7897/2277-4343.110226 NASYA WITH VILWADI GULIKA VS HINGVADI YOGA IN MILD TO MODERATE DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL Sahala Yasmin KC Jithesh M * Parvathee Devi MP 11 -0001 32 37 Depression is a state of low mood and aversion to activity that can affect a person__ampersandsignrsquo;s thoughts, behavior, feelings and sense of well-being. Globally depression is a common illness with an estimated 350 million people affected. Kaphajonmada, visada and cittavasada are similar conditions narrated in Ayurvedic parlance. Previous studies on Hingvadi Yoga nasya had proven its effect in depressive disorder. Efficacy of Vilwadi Gulika as nasya was observed from the clinical practice in depression, but no scientifically validated data available. 32 patients fulfilling the inclusion criteria were selected from OPD and IPD of VPSV Ayurveda college hospital and GARIM, Kottakkal, Malappuram, Kerala, India satisfying ICD-10 diagnostic criteria for mild to moderate depression. They were administered marsa nasya with Vilwadi gulika as trial drug and Hingvadi yoga gulika as control for 7 days, at the dosage of 2 ml for each nostril during morning hours (7-9 am). The effect of therapy was assessed with Hamilton__ampersandsignrsquo;s depression rating scale and Quality of Life Satisfaction and Enjoyment scale, before the procedure and on the 4th, 7th and on 10th day after nasya. Vilwadi gulika was found to be statistically significant at the level of p __ampersandsignlt; 0.001 in mild to moderate depression. Hingvadi yoga was also found to be statistically significant at the level of P __ampersandsignlt; 0.001. On comparison of Vilwadi gulika with Hingvadi yoga it was significant at p __ampersandsignlt; 0.05. Depression Kaphajonmada Vilwadi Gulika Hingvadi Yoga HAM-D