IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.130374 RECEIVER OPERATING CHARACTERISTIC CURVE ANALYSIS IN DIAGNOSTIC RESEARCH: A REVIEW Kalesh M Karun Amitha Puranik * 11 -0001 132 133 Optimal dose selection in clinical trials is problematic when efficacious and toxic concentrations are close. A receiver operating characteristic curve is a graphical technique used to identify the optimal cut-off point for a continuous variable. Implementation of ROC analysis is currently possible using various statistical software packages. However, the process is straightforward in the EZR package of R software. This present study aims to provide a tutorial using a simple example and a detailed description of the procedure in EZR software. The information provided can help the researchers perform the analysis independently. ROC curve diagnostic test sensitivity specificity