IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.130496 STHAULYA, AMA, AND MEDA DHATU, THE DYSFUNCTIONAL NUTRITIONAL METABOLISM WITH SPECIAL REFERENCE TO OXIDATIVE STRESS: A NARRATIVE REVIEW Amulya Murthy Aku * Ashok Patil Mukund Sabnis 11 -0001 95 98 Obesity and its accompanying consequences are increasingly linked to oxidative stress, as evidenced by a growing body of research. Several biochemical pathways, including superoxide production from NADPH oxidases and glyceraldehyde auto-oxidation, can cause systemic oxidative stress in obese individuals. Hyperleptinemia, inadequate antioxidant defence, chronic inflammation, and postprandial reactive oxygen species production contribute to oxidative stress. This Oxidative stress is related to or co-related to __ampersandsignldquo;Ama__ampersandsignrdquo;. Ama is generated by improper or insufficient digestion of food particles due to a lack of Jatharagni and Mala accumulation in the body. Modern physiology has linked Ama to potentially harmful Free radicals. It is essential to neutralize free radicals because they have one or more unpaired electrons. Oxygen-free radicals, or __ampersandsignquot;Reactive Oxygen Species,__ampersandsignquot; make up most dangerous free radicals. Ama is in the same boat as Avipakam (incompletely metabolized) due to its metabolism. This Ama brings on many diseases. Many diseases have been linked to free radicals. Sthualya Obesity Oxidative stress Ama Free Radicals NADPH