IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.1306159 SAFETY PROFILE OF CHAPALA BHASMA WITH SPECIAL REFERENCE TO BISMUTH AND SELENIUM Prasanna Mathad * MR Pandya Arathi Chandran JL 11 -0001 71 75 Rasashastra is the branch of elemental biology in Ayurveda and has utilized almost every substance in nature, ranging from simplest forms like mud, fossils, and resin, to the most precious things like gold, gems etc. Chapala is a rasa dravya included in the group of Maharasa. It is a controversial drug, some authors consider Chapala as Bismuth, and some believe it is Selenium. So, to resolve the controversy of Chapala, a study has been conducted. Aim: To understand the Safety profile of Chapala bhasma (clax) with reference to Bismuth and Selenium through oral toxicity study. Material and Methods: Clax of Bismuth and Selenium, and the study was carried out according to the OECD guidelines. Results: Bismuth Clax has shown considerable changes in histopathology reports and fewer changes in Selenium clax. Conclusion: The Chapala bhasma prepared by Bismuth and Selenium was nontoxic, and Selenium clax showed more safety profile than Bismuth clax. Bismuth bhasma (clax) Selenium bhasma (clax) OECD guidelines Physical observation Histopathology.