IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.1306171 PULSATILE DRUG DELIVERY SYSTEM: A REVIEW B. Gangadhar B. Sai Bhanu Sree * PV Swamy M. Aruna Devi 11 -0001 124 130 Pulsatile Drug Delivery Systems (PDDS) are gaining a lot of interest as the delivery of the drug will be at the right site and at the right time, and the amount of drug that is reaching the site of action will also be so accurate, and therefore it generally improves the patient compliance. These followed a sigmoidal drug release profile and were characterized by a time of no drug release followed by a rapid and complete drug release. This article focuses on the various types of methodologies involved for the existing system and different marketed technologies, including PulsincapTM, OROS, DIFFUCAPS, CODAS__ampersandsignreg;, TIMERx__ampersandsignreg;, and CONTIN__ampersandsignreg;, which follow the above mechanism to render a sigmoidal drug release profile, diseases requiring pulsatile drug delivery system, need for PDDS and evaluation of PDDS. Pulsatile drug delivery system sigmoidal drug release profile patient compliance.