IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.15120 PHYSICOCHEMICAL ANALYSIS OF SIDDHA POLY-HERBAL FORMULATION NELLIMULLI ILAGAM C. Poongkothai * K. Vennila M. Meenakshi Sundaram R. Meenakumari 11 -0001 94 97 Introduction: The Siddha system is an ancient, holistic system. The medicine in this system is prepared from raw materials of herbs, metals, minerals and animal products.__ampersandsignnbsp; In recent years, considerable research has focused on validation and standardisation aspects. Nellimulli ilagam is a polyherbal Siddha formulation used to manage Veluppu noi. Aim: To study the physicochemical analysis of Nellimulli ilagam. Methods: Standardization parameters such as organoleptic characteristics, physicochemical analysis, test for aflatoxins, pesticide residues, specific pathogens, and heavy metal analysis were carried out as per PLIM guidelines. Results: The results obtained from the trial drug Nellimulli ilagam study show that it has a dark, brownish-coloured semi-solid texture with a strong characteristic odour and is non-free-flowing. Physicochemical analysis reveals that pH was 7.2, total ash value was 10__ampersandsignplusmn;0.4 and acid insoluble ash value was 0.02__ampersandsignplusmn;0.004. Loss on drying at 105 0C is 8.4__ampersandsignplusmn;0.9. The test for aflatoxins and pesticide residues showed negative results. Test for microbial contamination and specific pathogen shows absent. Test for heavy metals shows below the limit of quantification (BLQ). Nellimulli ilagam Veluppu noi Physicochemical analysis Drug standardisation Siddha poly-herbal formulation.