IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.154134 A CRITICAL REVIEW ON EFFICACY OF VARIOUS CLINICAL TRIALS IN THE MANAGEMENT OF AMAVATA Akanksha Sharma * Vidula Gujjarwar Shrushti Rajender Nimje 11 -0001 128 131 In Ayurveda, it has been stated that Amavata (rheumatoid arthritis), once aggravated, is described as the disease having the highest incurable tendency among all the diseases. In modern science, it resembles rheumatoid arthritis and has been described as a crippling disease associated with severe pain, suffering, and diminished function, hence depriving the person of an optimal quality of life. This study is to assess various clinical trials that have been carried out for the management of Amavata (rheumatoid arthritis). Various clinical trials that have been conducted in various departments of different institutes have been tabulated with respect to the drugs used, their dose, mode of administration, sample size, type of study, duration of the trial, and the results obtained. After the course of treatment that varies from 15 days to 90 days, ayurvedic formulations and procedures like Kshara Basti, Vaitarana Basti, Shatyadi Kwath, Maharasnadi Kwath, Alambushadi Churna, Singhnaad Guggulu, Guduchi and Shunthi Kwath, Vatari Guggulu, Mritasanjeevana Rasa, etc. used in different trials showed highly significant (p__ampersandsignlt;0.001), significant (p__ampersandsignlt;0.01/ __ampersandsignlt;0.05), non-significant (p__ampersandsigngt;0.01/0.05) results in sandhi ruja, sandhi shotha, jadyata, aruchi, aalasya, sparsha ashatva, restricted range of motion and grip strength, general functional capacity, walking time, foot pressure; RA factor, ESR, CRP, DAS28 score. Amavata rheumatoid arthritis DAS 28 Score RA factor subjective parameters Grip Strength Walking time