IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.155158 A SINGLE-ARM CLINICAL STUDY TO EVALUATE THE COMBINED EFFECTIVENESS OF UDVARTANA AND ERANDAMOOLADI KALA BASTI IN THE MANAGEMENT OF HYPOTHYROIDISM Rosy Nandi Ashvini Kumar M Kavita MB * Krishna Teja Pooja PK 11 -0001 72 75 The lifestyle of the modern era has led to alternation in the activities of the neuro-endocrine system causing newer health challenges such as hypothyroidism. TSH value>4.5 mIU/L, is diagnosed as hypothyroidism with features of slow metabolic rate, weight gain, and dry and cool skin. The prevalence of hypothyroidism in India is 11%. Women are affected approximately 6 times more frequently than men. In Ayurveda, the clinical presentation of hypothyroidism can be understood in terms of santarpanotha vikara with tridosha dushti. The pathogenesis revolves around Ama which is formed by agnimandya with predominance of rasa and medodushti. Rukshana upakrama is the first opinion of therapy for such a condition. The study aims to evaluate the combined effectiveness of Udvartana and Erandamooladi Kala Basti in managing hypothyroidism. A total of 20 subjects diagnosed with hypothyroidism, aged between 20-60 years were given Udvartana and Erandamooladi Kala Basti for nine days. The assessment was based on body fat percentage, visceral fat percentage, serum TSH values, and Zulewski__ampersandsign#39;s clinical score. Statistical analysis showed a significant reduction in Visceral fat percentage, TSH value, and Zulewski__ampersandsign#39;s clinical score with p-value Erandamooladi Basti Hypothyroidism Udvartana Zulewski's clinical score Body fat percentage Visceral fat percentage.