IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.16241 EFFECT OF GURUPRAVARANA AS NIRAGNI SWEDANA AND VIRECHANA KARMA ON DYSLIPIDEMIA: A CASE REPORT Manjunatharao SV * Shreyas DM Kiran M Goud 11 -0001 47 51 Background: Dyslipidemia, marked by elevated LDL and triglycerides and reduced HDL, is a major risk factor for cardiovascular disease. In India, prevalence is estimated at 25–30% in urban and 15–20% in rural populations. In Ayurveda, dyslipidemia correlates with Medoroga, classified under Santarpanjanya Vyadhi, and traditionally managed through Vamana, Virechana, Swedana, and other therapies. Apatarpana Chikitsa, incorporating Langhana, Rookshana, and Swedana, is indicated for such conditions. Case Report: A 39-year-old male presented with increased cholesterol, weight gain, body heaviness, indigestion, sleep disturbances, and elevated blood pressure over two months. He followed a sedentary lifestyle and worked under chronic stress. Laboratory findings confirmed dyslipidemia: total cholesterol 200 mg/dL, LDL 82 mg/dL, triglycerides 110 mg/dL, and HDL 35 mg/dL. Ayurvedic evaluation revealed Kapha-Meda aggravation, warranting Shodhana therapy. Intervention: The patient underwent Rookshana therapy as Vishista Poorvakarma to pacify excess Meda and Kapha, followed by Niragni Swedana to reduce Gaurava (heaviness). Subsequently, Virechana Karma was administered to eliminate vitiated Pitta, Kapha, and Meda, improving liver function and metabolism. Treatments adhered to classical Panchakarma protocols. Outcome: Following therapy, the patient reported symptomatic relief and improved well-being. Post-treatment lipid profile showed significant improvement: cholesterol 168 mg/dL, LDL 80 mg/dL, triglycerides 68 mg/dL, and HDL 45 mg/dL. No adverse effects were observed. Conclusion: This case underscores the potential efficacy of Niragni Swedana (Gurupravarana) and Virechana Karma in managing dyslipidemia. Their purificatory and metabolic actions offer a promising integrative approach to treating metabolic disorders. Gurupravarana Niragni Swedana Virechana Karma Medoroga Dyslipidemia.