IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.165178 TECHNOLOGICAL INNOVATIONS IN SIDDHA DRUG MANUFACTURING: AN OBSERVATIONAL STUDY OF ASU PHARMACEUTICAL INDUSTRIES ACROSS TAMILNADU, INDIA Priyadarshini K * Mary Sharmila Lakshmi Kantham 11 -0001 107 114 This observational study investigates the technological innovations and infrastructural developments in Siddha pharmaceutical industries across Tamil Nadu. The research provides a detailed analysis of automated machinery, modern fermenting vessels, packaging improvements, preservatives, and quality control measures aligned with AYUSH and international standards. The study also documents research and development efforts focused on new proprietary formulations and standardization, showcasing the industry’s shift from traditional to large-scale production. Key infrastructural features such as segregated production areas and centralized packing sections are analyzed alongside the impact of mechanization affects efficiency and product consistency. While technological integration has enhanced mass production and regulatory compliance, challenges remain, including raw material scarcity, cost fluctuations, limited clinical validation, and slow modernization in smaller units. The study offers valuable insights into the current state of Siddha pharma industries, emphasizing the need for balanced modernization, improved quality assurance, and strategic marketing to promote sustainable growth and global acceptance. Siddha pharmaceuticals AYUSH labs automated machinery quality assurance traditional medicine.