IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.17127 AMSHAMSHA KALPANA OF KAPHA GUNAS: INTEGRATIVE INSIGHTS INTO THE CLINICAL PHENOTYPE OF PRAMEHA C Krishna Devaki * Gujjarwar Vidula S Sringa Aswini 11 -0001 158 162 Prameha, a complex metabolic disorder analogous to type 2 diabetes mellitus, originates from the qualitative disturbances in Kapha. Amshamsha Kalpana promotes an in-depth examination of how specific attributes of Kapha facilitate early pathogenesis. Kapha, in its normal state, sustains vitality and metabolic stability. However, when vitiated, its excessive qualities weaken Agni, promote Kleda formation, and obstruct microchannels, eventually disrupting normal Medo Dhatu development. The Purvarupa of Prameha, as described in the classics, shows remarkable similarities with modern concepts of insulin resistance, adipokine-mediated inflammation, oxidative stress, neuropathic changes, protein degradation, altered salivary composition, xerostomia, and glycosuria. The interrelation between Kapha and Medo Dhatu matches the fat-driven inflammatory process and impaired insulin signalling central to type 2 diabetes. Amshamsha Kalpana, which explores the attributes of Kapha, offers a structured framework to integrate classical Ayurvedic concepts with current biomedical knowledge, thereby contributing to future research on Kapha Guna-based clinical markers and the validation of Prameha Purvarupas as early indicators of metabolic disorders. Kapha Gunas Prameha Purvarupa Amshamsha Kalpana Medo Dhatu Dushti Diabetes