IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.17267 A REVIEW ON HARNESSING GENOMIC INSIGHTS FOR TAILORED AYURVEDIC INTERVENTIONS: A NEW PARADIGM IN PATIENT CARE Ravi Dalal * Rishita Gohel Sushant Sud Megha Pandya 11 -0001 151 153 Genomics has revolutionized healthcare by enabling individualized diagnostics and therapies, aligning closely with Ayurveda’s age-old focus on personalized medicine through Prakriti and Vikriti. This review explores a framework for integrating genomic insights with Ayurvedic principles to enhance treatment precision. It analyzes studies correlating Prakriti types with gene polymorphisms such as CYP2C19, GSTT1, and HLA-DRB1, which influence drug metabolism and disease susceptibility. National initiatives like the AYUSH Genomics Consortium and CSIR’s GENOMET project provide foundational datasets for this integration. Emerging evidence supports the Ayurgenomics approach—linking constitutional typing with genomics and pharmacogenomics—to enable tailored Ahara (diet) and Vihara (lifestyle) recommendations. Despite promising strides, challenges remain, including non-standardized assessments and limited sample sizes. Integration with multi-omics technologies presents a path toward validating Ayurvedic wisdom within the P4 medicine paradigm. Ayurveda Genomics Personalized Medicine Prakriti Pharmacogenomics Integrative Medicine P4 Medicine