IJRAP International Journal of Research in Ayurveda and Pharmacy 2277-4343 Moksha Publishing House 10.7897/2277-4343.17279 A REVIEW ON CONCEPTUAL EVALUATION OF PATHYA- APATHYA IN RASACHIKITSA WITH REFERENCE TO FOOD–DRUG INTERACTIONS Pallavi J. Buddhe * Hitesh A Vyas 11 -0001 202 205 Pathya-Apathya (wholesome-unwholesome) diet and lifestyle are the fundamental principles in Ayurveda, prescribed according to disease conditions to enhance treatment outcomes. In the context of Rasachikitsa, classical texts emphasize specific Pathya and Apathya guidelines according to Rasoushadhis. This is because Rasoushadhis are Vijatiya Dravya, i.e. Nirendriya Dravya includes heavy metals, minerals. They differ from Sajatiya dravya, which are easily metabolized in the body. Rasoushadhis, despite undergoing Shodhana and Samskara, retain potent properties and may interact differently with dietary substances after administration. In present era, medicines are frequently taken without medical consultation. Neglect of Pathya–Apathya principles in Rasachikitsa increases risk of altered drug-food interactions and hazardous outcomes. This paper highlights probable Rasoushadhi- drug interactions and their impact on the body. Analysis indicates that Samyoga of Rasoushadhi with specific dietary substances may lead to either, reduced or exaggerated drug action or adverse drug reactions. For instance, when Kampilaka interacts with Nagveli Patra, the Rechana Karma of Kankushtha is significantly enhanced, resulting in Atiyoga. Conversely, substances belonging to the Kakarashtaka Varga inhibit the absorption of Parada within the body, thereby limiting its therapeutic utility. Similarly, Kulatha interacts with Shilajatu by breaking it down in the body, which diminishes the potency and effectiveness of Shilajatu. Hence knowledge of Pathya- Apathya is crucial in Rasachikitsa as it regulates Rasoushadhi–diet interactions, ensuring safe metabolism, preventing adverse effects, and enhancing therapeutic efficacy. Adverse drug reactions Food- drug interactions Pathya- Apathya Rasachikitsa.