Article: EVALUATION OF NEPHROPROTECTIVE AND ANTI-NEPHROTOXIC PROPERTIES OF MUNIPRABHA PLUS TABLET

Article Category: Original Research articles

DOI: 10.7897/2277-4343.096173

Pages: 64-70

Author: Badekila Sathyanarayana *

Abstract: Background: Chronic renal failure (CRF) refers to an irreversible deterioration in renal function, which develops over a period of years. The conventional approach of management includes dialysis and renal transplantation, which are not affordable by Indian population mainly due to economic reasons. Muniprabha plus is a safe and effective polyherbo-mineral Ayurvedic nephroprotective product designed and developed to treat chronic renal disease. Objective: The experiment was conducted to study the effect of Muniprabha plus tablet against Gentamicin induced Nephrotoxicity in male Sprague dawley rats.  Materials and methods: 24 Sprague dawley rats between the range of 200 -300g were selected and acclimatized for a period of 5 days to the laboratory condition. After acclimatization, animals were randomized into four groups (Group I – IV) consisting of six animals per group. Group I and II animals received vehicle (0.5% CMC); group III and IV received Muniprabha plus tabletat 100 and 200 mg/kg b.wt.,p.o., respectively for a period of 14 days. After 1 hr of drug administration, allexperimental animals received Gentamicin (100 mg/kg; i.p) intraperitoneally once daily except those from normal control group for 14 days. Weekly drug dosage was adjusted based on the respective week body weight of animals. Result: The result of this study demonstrates that Muniprabha plus tablethas potent nephroprotective action upon Gentamycin-induced renal damage in rats and possessed anti lipid peroxidative and free radical scavenging activities Conclusion: Study indicates that Muniprabha plus is a promising nephroprotective drug 

Keyword: Nephroprotective, anti-nephrotoxic, Muniprabha plus, Ayurvedic herbomineral product