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International Journal of Research in Ayurveda and Pharmacy


ISSN Online:2229-3566

ISSN Print: 2277-4343

Article: EFFICACY OF TUKHM-E-SUDDAB (RUTA GRAVEOLENS) IN THE MANAGEMENT OF SALABAT-E-NABZ (ATHEROSCLEROSIS): A RANDOMIZED, SINGLE BLIND, PLACEBO CONTROLLED CLINICAL TRIAL

Article Category: Original Research articles

DOI: DOI: 10.7897/2277-4343.100112

Pages: 49-54

Author: Iram Naaz, Mohd Shahid *, Tanzeel Ahmad

Abstract: Aim:Presently, atherosclerosis is one of the prime threats worldwide as only in India CVD causes 37 million deaths annually raised by 59% from 23.2 million in last two decades which is higher than the global average. The standard treatment available for it had appalling side effects in long terms. This condition can be correlated to Salabat-e-Nabzin Unani system of medicine, treated since centuries through numerous compounds and single drugs. Tukhm Suddab(Ruta graveolens) is one of the single drugs which is indicated for the same, but has not been evaluated on the scientific parameters. Thus, a randomised, single blind placebo controlled clinical study was designed with an objective to determine the efficacy and safety of Tukhm Suddab(Ruta graveolens) in the management of Salabat-e-Nabz(atherosclerosis). Methods: The present clinical trial was a single blinded, randomized, placebo control study conducted at NIUM hospital, Bangalore, on sample size of 40 patients. Test group was treated with three capsules twice a day (each capsule contain 1 gm powder of test drug) and control group was treated with same dose filled with wheat flour for consecutive 90 days. Objective parameters and BP were assessed at every 15thday from baseline to 90thday of treatment in each group respectively. Result: Significant results were observed in right ABI (p




Keyword: Salabat-e-Nabz, Atherosclerosis, Ankle Brachial Index. Arterial Stiffness Index, LDL, Tukhm-e-Suddab, Unani, CTRI