Article: STUDY ON ANTIDIARRHEAL ACTIVITY OF RASA PARPATI IN RATS

Article Category: Original Research articles

DOI: 10.7897/2277-4343.100360

Pages: 49-51

Author: Anuroopa H K *, Suman, Hanumanthachar Joshi, Charan C.S.

Abstract: Background: Diarrheal disease is a leading cause of mortality and morbidity, especially in developing countries and is responsible for the death of millions of people each year. Rasa parpati is mainly indicated in Gastro Intestinal disorders which is recommended for Irritable Bowel Syndrome and diarrhea. However, there is no scientific data available on anti diarrheal activity. Hence the research work has been undertaken to find out the safety and efficacy of Rasa parpati. Aims and objectives: To evaluate the antidiarrheal property of Rasa parpati. Methods: The oral toxicity study using Albino rats was performed in accordance with OECD guidelines. The antidiarrheal activity of Rasa parpati was investigated against castor oil induced diarrhea in rats using Loperamide as the standard reference drug. The antidiarrheal activity was evaluated using parameters such as number of episodes, enteropooling and intestinal motility. Results: Rasa parpati was safe even in its higher dose and efficacious in reducing the frequency and severity of diarrhea against castor oil induced diarrhea and caused a significant decrease of the intestinal fluid accumulation and it delayed the intestinal transit of charcoal meal in trial animals as compared to the control and the results were statistically significant. Conclusion: Experimental findings showed that Rasa Parpati possess significant antidiarrheal activity by inhibiting the intestinal hyperactivity and hypersecretory effect in diarrhea.

Keyword: Rasa parpati, castor oil induced, enteropooling, intestinal motility, anti diarrheal activity.