Article: EFFECT OF YAVANI ARKA (HYDRO DISTILLATE OF TRACHYSPERMUM AMMI) ON RAT ILEUM, AGAINST ACETYL CHOLINE INDUCED CONTRACTIONS  

Article Category: Original Research articles

DOI: 10.7897/2277-4343.100364

Pages: 66-70

Author: Shweta Paul *, Karunanidhi Sharma

Abstract: Yavani or Trachyspermum ammi is an important drug used in traditional systems of medicines to treat gastrointestinal disorders like indigestion, colic, and diarrhea. Yavani and its distillate (Arka) has been indicated in classics to treat Agnimandya (digestive impairment), Anidra (Insomnia), Atisara (Diarrhea), Klaibya (Impotency) and Grahani (Irritable Bowel Syndrome). To evaluate its effect on smooth muscle of gastro intestine, the present study has been planned. Isolated rat ileum was hanged and balanced in organ bath assembly; Tyrode solution (for nutrition), temperature of 37°C and Oxygen (through aerator device) were maintained in the assembly (inner tube, where tissue was mounted), to keep the tissue alive. Contraction was induced by Acetylcholine. Then the response of Yavani Arka was observed at the dose of 0.5 ml, 1 ml, 1.5 ml and 2 ml/ 40 ml Tyrode solution. Relaxation effect or antispasmodic activity of Yavani arka was observed on all the contraction. The Effective Concentration for 50% effect (EC₅₀) was found to be 0.0165 ml/ml.

Keyword: Ajawain, Arq-e-ajavain. Ajavayana Arka. Arka Kalpana, Smooth muscle.