Article: HEPATOPROTECTIVE ACTIVITY OF PTEROCARPUS MARSUPIUM HEARTWOOD AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN FEMALE ALBINO WISTAR RATS

Article Category: Original Research articles

DOI: 10.7897/2277-4343.100490

Pages: 76-81

Author: Jadhav Anil G., Dhikale Rupali S.*, Patil Mrutyunjay B.

Abstract: present study is designed to investigate the hepatoprotective activity of Pterocarpus marsupium heartwood against carbon tetrachloride (CCl₄) induced hepatotoxicity in female Albino Wistar rats. Forty-two Albino Wistar female rats were divided in to seven equal groups each containing six animals. The shade dried heartwood of Pterocarpus marsupium was subjected for extraction by continuous hot extraction with petroleum ether (40- 60^oC), chloroform, alcohol and water. All the extracts (200 mg/kg) were evaluated for their hepatoprotective activity in CCl₄ induced hepatotoxicated rats. Hepatotoxicity induced rats were orally treated with extracts for 5 days. Four groups received the different extracts of Pterocarpus marsupium heartwood and intraperitoneal (i.p.) administration of CCl₄ (2 ml/kg). One group was control, one treated with CCl₄ and one group received standard drug Liv-52. The hepatotoxicity was assessed by plasma concentration of serum bilirubin and enzymes activities. Biochemical analysis and histopathology studies were performed to support the hepatoprotective activity. Among all the extracts, the aqueous extract (200 mg/kg) of Pterocarpus marsupium heartwood significantly reduced carbon tetrachloride induces damages in the liver, which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. Histopathological examination also supported the hepatoprotective effect of aqueous extract (200 mg/kg) of Pterocarpus marsupium heartwood.

Keyword: Pterocarpus marsupium, heartwood, carbon tetrachloride, hepatoprotective.