Article: A REVIEW ON DRUG INDUCED LIVER INJURY: A RETROSPECTION

Article Category: Review articles

DOI: 10.7897/2277-4343.100598

Pages: 17-21

Author: Aiswarya PJ *, Lekshmi S, Subash Philip

Abstract: Drug-induced liver injury (DILI) is an infrequent condition but can become potentially dangerous due to various factors. The triggering factors of liver disease are often associated with Over the Counter (OTC) medicines, prescription medications, and herbal and dietary supplements (HDS). DILI are of two types: intrinsic and idiosyncratic. Risk factors for idiosyncratic DILI (IDILI) are frequently associated with multiple hosts, environmental and compound factors. The formation of international syndicates for the registry made it advantageous for conducting the study of individual predispositions to DILI. Recent data highlight antibiotics, central nervous system agents, anti-tubercular drugs, herbal/dietary supplements and immunomodulatory agents as the most common causes of DILI. Female patients are often affected by this disorder. Treatment modalities range from the use of nanotechnology to provide hepatoprotective agents directly to the liver, up to polyherbal formulations. Future areas of research include the identification of predisposing factors in the patients at highest risk for DILI.

Keyword: Drug – Induced Liver Injury (DILI), Registries, Herbal Medications, Risk Factors