ISSN Print: 2277-4343
Article: A PHARMACEUTICO–ANALYTICAL STANDARDIZATION OF DURJALAJETA RASA PREPARED BY CLASSICAL METHOD
Article Category: Original Research articles
DOI: DOI: 10.7897/2277-4343.1005103
Author: Mudliyar Anuradha *, Sathyanarayana B
Abstract: Durjalajeta Rasa is a Herbo-mineral preparation mentioned in Rasa Chandamshu. It is one of the khalviyarasayana. The main ingredients are Shuddha vatsanabha (Aconitum ferox Wall.), Kapardika Bhasma (Cypraea moneta Linn.) and Maricha (Piper nigrum Linn.) The aim is to prepare Durjalajeta Rasa according to classical method mentioned in Rasa Chandamshu with due importance to Standard Operative Procedure and to carry out physico-chemical analysis of three different samples of Durjalajeta Rasa and to standardize the same. Durjalajeta Rasa is prepared by grinding the fine powders of the Shuddha Vatsanabha, Kapardika Bhasma and Maricha in the ratio 2:5:9 respectively with ardraka swarasa for 6 hours and final product obtained in the form of Vati (pills) form. Analytical study of final product is carried out by basic quality control parameters such as average weight, uniformity of weight of pills, disintegration test,thin layer chromatography, and subjected for advanced instrumental methods of analysis like XRD, SEM-EDAX, ICPMS and HPTLC and it is observed that sample DJR1, DJR2, DJR3 are spherical, rough, gray coloured and hard in consistency. The uniformity of weight of pills, hardness, disintegration, friability of samples of Durjalajeta Rasa is approximately similar. EDAX and ICPMS showed presence of carbon, oxygen, calcium, magnesium, sulphur, potassium, chlorine, iron and copper. All major peaks observed in all sample indicate calcite as the major phase. The three samples of Durjalajeta Rasa prepared showed almost similar results in all the analysis carried out.
Keyword: Durjalajeta Rasa, Disintegration, X-Ray Diffraction, Thin layer chromatography