Article: AN IN VITRO STUDY OF RASAKRIYA AND ETHANOLIC EXTRACT OF CHITRAKA (PLUMBAGO ZEYLANICA LINN.) FOR ITS THROMBOLYTIC ACTIVITY WITH SPECIAL REFERENCE TO “KATUKO RASA SHONITA SANGHATAM BINNATI”

Article Category: Original Research articles

DOI: 10.7897/2277-4343.110231

Pages: 61-65

Author: Soujanya B. , Shubha V. Hegde *, Priyanka Adiga, Kiran M. Goud

Abstract: Blood coagulation causes many serious health problems like Myocardial infarction, deep vein thrombosis, renal vein thrombosis etc which are treated with thrombolytic drugs to dissolve the blood clots in modern system of medicine. Thrombolytic agents have certain limitations. Apart from dissolving the clots it also causes serious and occasionally fatal consequences. Herbs and herbal medicines are known for their efficacy in treating diseases effectively without producing any untoward effects. Herbs that are having Katu rasa are known to cause thrombolysis. Hence the research was aimed at understanding and developing rational model to understand action of drug as thrombolytic agent based on classical reference in Ayurvedic science “Katuko rasa shonitasanghatambhinnati” by doing an In vitro study of Chitraka Rasakriya and Ethanolic extract of Chitraka (Plumbago zeylanica Linn) for its thrombolytic activity at different dosage using Streptokinase as positive control and distilled water as negative control. Chitraka (Plumbago zeylanica Linn) is having Katurasa, katuvipaka, ushnaveerya, laghurookshateekshnaguna. Blood samples were treated with different dosage of Chitrakarasakriya and Ethanolic extract of Chitraka and compared with Streptokinase as positive control and Distilled water as negative control. Results were assessed based on difference of clot weight before and after treatment for its clot lysis efficacy. Study results showed Chitraka Rasakriya and Ethanolic extract of Chitraka possess thrombolytic activity which is statistically highly significant. Chitraka Rasakriya had better thrombolytic activity when compared to Ethanolic extract of Chitraka and Streptokinase as positive control.

Keyword: Rasakriya, thrombolytic, shonitasanghatambinnati.