ISSN Print: 2277-4343
Article: SAFETY EVALUATION IN ICR MICE OF LINK LIVECARETM: A HEPATOPROTECTIVE POLYHERBAL FORMULATION
Article Category: Original Research articles
Author: Karunarathna Amila Ureshani, Chandrika Udumalagala Gamage, Padumadasa Chayanica, Seneviratne Bimalka, Abeysekera Ajita Mahendra *
Abstract: Link livecareTM is a polyherbal formulation consisting of fourteen medicinal plants. The hepatoprotective activity of an extract of Link livecareTM against carbon tetrachloride and galactosamine induced hepatotoxicity in mice has been reported previously with an optimal dose of 80 mg/kg body weight. Acute, sub-acute and sub-chronic oral toxicity of Link livecareTM were studied in mice, in accordance with OECD procedures utilizing a range of histological, biochemical and haematological parameters. No toxic effects were observed at a single dose at 2000 mg/kg body weight or with daily doses ranging from 80 mg/kg body weight to 400 mg/kg for periods of fourteen days and ninety days. These results support the safety claims for Link livecareTM.
Keyword: Link livecareTM, polyherbal hepatoprotective formulation, safety evaluation, acute toxicity, sub-acute toxicity, sub-chronic toxicity.