Article: SAFETY EVALUATION IN ICR MICE OF LINK LIVECARE^TM: A HEPATOPROTECTIVE POLYHERBAL FORMULATION

Article Category: Original Research articles

DOI: 10.7897/2277-4343.110233

Pages: 70-76

Author: Karunarathna Amila Ureshani, Chandrika Udumalagala Gamage, Padumadasa Chayanica, Seneviratne Bimalka, Abeysekera Ajita Mahendra *

Abstract: Link livecare^TM is a polyherbal formulation consisting of fourteen medicinal plants. The hepatoprotective activity of an extract of Link livecare^TM against carbon tetrachloride and galactosamine induced hepatotoxicity in mice has been reported previously with an optimal dose of 80 mg/kg body weight. Acute, sub-acute and sub-chronic oral toxicity of Link livecare^TM were studied in mice, in accordance with OECD procedures utilizing a range of histological, biochemical and haematological parameters. No toxic effects were observed at a single dose at 2000 mg/kg body weight or with daily doses ranging from 80 mg/kg body weight to 400 mg/kg for periods of fourteen days and ninety days. These results support the safety claims for Link livecare^TM.

Keyword: Link livecareTM, polyherbal hepatoprotective formulation, safety evaluation, acute toxicity, sub-acute toxicity, sub-chronic toxicity.