Article: RISK FACTORS AND CURRENT STRATEGIES TO OVERCOME ALZHEIMER’S DISEASE: A REVIEW  

Article Category: Review articles

DOI: 10.7897/2277-4343.110373

Pages: 115-123

Author: Ranjitha C J *, Manjunatha P Mudagal

Abstract: Alzheimer's disease is currently the biggest health care issue in developing countries. There is still no effective therapy that can slow the progression of disease. This is the most common cause of dementia among people aged 65 and older. It affects 10% of people over 65 years of age and 50% over 85 years of age. This phase of neurodegenerative disease is marked by two distinctive pathologies: β-amyloid plaque deposition and hyperphosphorylated tau neurofibrillary tangles. Pathology and Possible Risk factors have been extensively included in this review. It also reviewed about currently available drugs with their drawbacks. Treatment is primarily focused on symptomatic treatment, while there are ongoing studies aimed at reducing the development and overall disease burden within the brain. Here, we are discussing recent developments in our perception of Alzheimer's disease clinical assessment and treatment, with updates on clinical trials still taking place. It also includes some protective measures to overcome by Alzheimer’s.

Keyword: Alzheimer’s disease, Dementia, ?-Amyloid, Hyperphosphorylated Tau, ?-secretase