Article: NEBULIZATION WITH HARIDRA ARKA VERSUS METERED DOSE INHALER IN ACUTE EXACERBATION OF BRONCHIAL ASTHMA: AN OPEN LABEL, NON-RANDOMIZED, NON-INFERIORITY TRIAL

Article Category: Original Research articles

DOI: 10.7897/2277-4343.110486

Pages: 40-44

Author: Anusree D. *, Manoj Kumar A K, Subin V R, Nidhin P. S

Abstract: Intranasal drug delivery especially in respiratory diseases has solemnly increased over past years owing to the pollution, especially in bronchial asthma. Advancements in treatment of Asthma came into light with the introduction of Nebulization. So if ?yurveda drug formulations can be used by incorporating modern technologies to manage acute exacerbations, it will help asthmatics to minimize their sufferings. On this line a study was designed to study the efficacy of Nebulization with Haridr? Arka versus Metered dose inhaler in acute exacerbation of bronchial asthma. The objectives of this study were to find out efficacy of Nebulization with Haridr? Arka in acute exacerbation of Bronchial Asthma and to compare efficacy of Nebulization with Haridr? Arka against Metered Dose Inhaler in acute exacerbation of Bronchial Asthma. Thirty participants satisfying the diagnostic criteria of Bronchial asthma, selected from the OPD of Panchakarma were equally divided into two groups by convenience sampling. Group A was given Nebulization with Haridr? Arka and Group B participants - Metered dose inhaler (Salbutamol). Assessments were done before and after treatment with the help of subjective and objective pulmonary parameters. Statistical analysis was done using SPSS 16 and Instat graph pad 3.1. In Group A improvement was seen in intensity of wheeze, sputum production, FEV1/FVC% whereas in Group B better results were obtained in parameters like cough, FVC, PEFR per sec. Equal effectiveness seen on breathlessness, chest tightness, FEV1 values. Nebulization with Haridr? Arka can be safely and effectively administered in providing instantaneous relief in acute exacerbation of bronchial asthma, both in OPD and IPD based settings.

Keyword: Haridr? Arka, Metered dose inhaler, Nebulization, ?yurveda