Article: EVALUATION OF EFFICACY OF HERBAL PREPARATION IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS: A STUDY

Article Category: Original Research articles

DOI: 10.7897/2277-4343.1104107

Pages: 152-160

Author: Roop Ganguly, Vibha Singh *, Abhay Narayan Tiwari, Shadab Mohammad, Uma Shankar Pal, Seema Gupta, Ranjana Singh, Shalini Gupta

Abstract: Oral submucous fibrosis is a chronic debilitating disease and a well-recognized potentially premalignant condition of the oral cavity, various medical and surgical modalities have been used but results are not satisfactory owing to recurrence, adverse effects and some worsening condition. Our study comprised of 30 patients attending the department of Oral and Maxillofacial surgery, King George’s Medical University, Lucknow, India. It was open-label randomized clinical trial 30 patients of clinically diagnosed cases of oral submucous fibrosis. The herbal preparation was made and given to the patients for oral rinse and gargle for 3-5 minutes twice a day for 4 months. Clinical evaluation was done every 15 days. Pre and post-interventional evaluation of biochemical parameters, serum antioxidant, Malondialdehyde, Superoxide dismutase and Glutathione peroxidase were done. There was a marked improvement in clinical as well as biochemical parameters. The herbal preparation is effective in reducing burning sensation, intolerance to spicy food, pain in mouth opening, bringing change in the colour of mucosa from white to red, reduction of blackening of oral mucosa.

Keyword: Burning sensation, Sphaeranthus indicus, mouth opening, Ocimum sanctum, oral sub-mucous fibrosis, Tulsi, honey