Article: AN EXPERIMENTAL STUDY TO EVALUATE CARDIOPROTECTIVE ACTIVITY OF JINGINI LANNEA COROMANDELICA MERR (HOUTT): AN IN VIVO STUDY

Article Category: Original Research articles

DOI: 10.7897/2277-4343.1106182

Pages: 37-46

Author: Rachana K. L. *, Giri Prashanth K.G, Manjunatha P. Mudagal, Seema Pradeep, Yashaswini B.K, Varuni B.G.

Abstract: Jingini - Lannea coromandelica Merr. (Houtt) is mentioned in Bhava Prakasha Nighantu and Bhavamishra advocates JINGINI for Hridroga. An experimental study was designed with a Model - Isoproterenol (ISO) Induced Cardiac toxicity in order to prove the efficacy of JINGINI for its Cardioprotective activity. Animals were administered with Aqueous and Methanolic extract of JINIGINI in higher and lower dose. The Acute toxicity studies were conducted up to 5000 mg/kg body weight in accordance with OECD 425 guidelines. The higher dose calculated from 1/5^th of 5000 mg/kg body weight which summed up to 1000 mg/kg body weight and lower dose calculated from 1/10^th of 5000 mg/kg body weight was concluded as 500 mg/kg body weight. The Methanolic extract of JINGINI in Higher and Lower dose (1000 mg/kg body weight and 500 mg /kg body weight respectively) was found to be efficacious in providing the Cardio-protective action in SD Rats.

Keyword: Jingini, Cardioprotective activity, Isoproterenol (ISO)