Article: AN EXPERIMENTAL EVALUATION OF VEDANASTHAPANA EFFECT OF JALAVETASA AND DEVADARU: A COMPARATIVE STUDY

Article Category: Original Research articles

DOI: 10.7897/2277-4343.120110

Pages: 34-42

Author: Dinesh Kumar P. M. *

Abstract: Symptoms like pain is perhaps one of the important aspects to study in detail, because in almost all disease manifestation pain is accompanied and it is the common symptom which brings a patient to physician. So, search for safe drug preparations, which are much effective with very fewer side effects, are from herbal remedies, is the necessity of the present age. To treat the vedana (Pain), Devadaru (Cedrus deodera Roxb. Loud) and Jalavetasa (Salix tetrasperma Roxb.) are the drugs found to be very effective. ‘Vanjula’ is the synonym to Jalavetasa, which included under Vedanasthapana Mahakashaya (group of ten analgesic dravya) by Charaka Samhita¹. In this study Devadaru and Jalavetasa has been selected to evaluate its efficacy in Vedanasthapana action. The efficacy of the drugs has been evaluated through experimental studies. The aim is to evaluate the Vedanasthapana (Analgesic) property of Jalavetasa and Devadaru on Albino mice through animal experimentation using Hot Plate Method. Study has been undertaken as pre-clinical method. In-vitro method on Albino mice. Four trial groups have included to evaluate the Vedanasthapana (Analgesic) action. Control group, Standard drug group. Group- 1- Devadaru, Group-2- Jalavetasa. Control group has no significance. Trial group 1 & 2 have significance. Standard group has shown marked significance throughout the study. Interpretation: Gradual increase in action has been observed in the trial groups. The standard group has shown immediate onset of action but same progress has not maintained after 90 minutes. The trial drugs Devadaru and Jalavetasa have sustained analgesic action as observed by experimental study.

Keyword: Cedrus, Salix, Vedanasthapana, Analgesic, Kwatha, Hot plate.