Article: ROLE OF GUDUCHI TINOSPORA CORDIFOLIA (WILLD) MIERS. IN COUNTERACTING THE ADVERSE DRUG REACTIONS INDUCED BY ANTIDEPRESSANT DRUGS

Article Category: Original Research articles

DOI: 10.7897/2277-4343.120367

Pages: 25-30

Author: Mamatha Sri S *, K.S. Jayashree

Abstract: In the present scenario psychosomatic stressful situation is been increasing which has resulted in increased incidence in Psychiatric disorders. The prevalence of all mental disorders was observed to be 65.4 per 1000 population. In 2017, 197.3 million people had mental disorders in India, including 45.7 million with depressive disorders and 44.9 million with anxiety disorders. Depression and other mood disorders need long term treatment. Among antidepressants SSRI group of drugs are more frequently advocated followed by Tricyclics. Due to long term medications, patients often complaints of adverse drug reactions which many times leads to discontinuation of treatment. In this study Guduchi was chosen to address the ADRs induced by antidepressant drugs at GI level. It was a randomized single blind comparative clinical study, where 40 volunteers undergoing antidepressant treatment and have developed ADRs were selected. Subjects were randomly assigned into two group A and B with 20 patients each. Guduchi Rasakriya 1 gram in divided dose was given to group A and symptomatic conventional treatment to group B. It was observed that Guduchi was effective in major number of problems raised in GIT like Dryness of mouth, Gastric irritation, Nausea, Anorexia, Loose stools. In this clinical study Guduchi ghanasara (rasakriya) exhibited significant response in adverse drug reactions at the level of GIT induced by Antidepressant drugs (SSRI and Tricyclics) when compared to conventional symptomatic treatment.

Keyword: Guduchi, Tinospora cordifolia, Adverse drug reactions, Antidepressant drugs, SSRI.