Article: PHYSICOCHEMICAL STANDARDISATION OF SIDDHA TABLET PREPARATION JATHIKAAI MATHIRAI

Article Category: Original Research articles

DOI: 10.7897/2277-4343.1204112

Pages: 87-93

Author: K. Rajeswari *, M. Supritha Muthu, K. Vennila, M. Meenakshi Sundaram, R. Meenakumari

Abstract: The aim of this study is to standardize the herbal Mathirai preparation Jathikaai Mathirai based on qualitative and quantitative methods as per the analytical specifications of Tablet/Mathirai prescribed by the Protocol testing of ASU drugs by Pharmacopoeial laboratory for Indian Medicines. The Tablet is prepared as described in the text Bala Vagadam. The medicine is subjected to Physicochemical standardisation as per the pharmacopoeial laboratory standards of Indian medicine. The tablet is in solid form which is brown in colour. It is rigid with strong characteristic odor. The aflatoxin assay and pesticide residue revealed that the tablet is free of aflatoxins and pesticide residue. The formulation is free of microbial contamination and shows positive for the presence of steroids, alkaloids, coumarins, tannins, carbohydrates, glycosides etc. The heavy metals are below detectable limit. The result of HPTLC finger printing of the drug at UV 366 nm shows that the peak at Rf 0.02 constitutes 100% of the total area of the separated peaks, which denotes the abundant existence of the drug at minimum peak level itself. It indicates drug as phytochemicals. The result of the present study ensures the safety profile of the Jathikaai Mathirai – Siddha herbal Tablet intended for paediatric usage and indicative of presence of active phytoconstituents that are responsible for its efficacy in treating the Valippu Noi (Seizure disorder) in children.

Keyword: Jathikaai Mathirai, Valippu Noi, Seizure disorder, Physicochemical analysis, Phytochemical analysis.