Article: IN VIVO STUDY OF COLON CANCER WITH SPECIAL REFERENCE TO INDUCER 1,2-DIMETHYLHYDRAZINE (DMH) AND STANDARD DRUG 5-FLUOROURACIL (5-FU): A REVIEW

Article Category: Review articles

DOI: 10.7897/2277-4343.130367

Pages: 96-100

Author: Sarang A. Paulzagade *, Uday V. Pawade, Ashwin V. Nikam, Meghsham P. Anjankar

Abstract: Cancer is a group of diseases caused by loss of cell cycle control. Cancer is associated with abnormal, uncontrolled cell growth. Colon cancer is the second most common cancer in females and the third most in males worldwide. The rate of colon cancer was low in India. But at present, it is increasing out 3.5 million cancer cases, 35,000 have colon cancer. Polyps, which are the small growths in the colon, are most often benign, even though some have the potential to become cancerous. For cancer treatment, 5-Fluorouracil (5-Fu) is commonly used as a chemotherapeutic drug. 1,2-Dimethylhydrazine (DMH) is a potent colon carcinogen inducer. These colorectal tumours share many resemblances to human colorectal cancer, including similar responses to promotional and preventive agents. This review article highlights various In vivo studies on colon cancer induced by 1,2-Dimethylhydrazine (DMH) and treated by standard drugs with the help of parameters like Aberrant crypt foci (ACF), Histopathology of the colon, Haematological parameters etc.

Keyword: Colon Cancer, In vivo study, 5-Fluorouracil (5-FU), 1,2-Dimethylhydrazine (DMH).