Article: RECEIVER OPERATING CHARACTERISTIC CURVE ANALYSIS IN DIAGNOSTIC RESEARCH: A REVIEW

Article Category: Review articles

DOI: 10.7897/2277-4343.130374

Pages: 132-133

Author: Kalesh M Karun, Amitha Puranik *

Abstract: Optimal dose selection in clinical trials is problematic when efficacious and toxic concentrations are close. A receiver operating characteristic curve is a graphical technique used to identify the optimal cut-off point for a continuous variable. Implementation of ROC analysis is currently possible using various statistical software packages. However, the process is straightforward in the EZR package of R software. This present study aims to provide a tutorial using a simple example and a detailed description of the procedure in EZR software. The information provided can help the researchers perform the analysis independently.

Keyword: ROC curve, diagnostic test, sensitivity, specificity