Article: DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE

Article Category: Original Research articles

DOI: 10.7897/2277-4343.130491

Pages: 72-77

Author: P. Srikanth Reddy *, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi 3, D. Saritha

Abstract: An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solubility study, and dissolution study. Immediate release tablets were prepared using various polymers, and the prepared tablets were evaluated for weight variation, friability, assay, hardness, thickness, disintegration test and dissolution test. The Nateglinide immediate release tablet (F2) showed 58.72% drug release within the first 5 min. and 99.50% drug release within 30 min. The results showed that the formulation satisfied the objective of fast disintegration, dissolution, % friability, hardness, wetting time, water absorption ratio, ease of administration and safety. The success of the present study recommends a detailed investigation into in-vivo studies for its effective use in clinical practice.

Keyword: Nateglinide, PEG6000, immediate-release tablets