Article: FORMULATION AND EVALUATION OF TOPICAL GEL OF RUBIA CORDIFOLIA (MANJISTHA)

Article Category: Original Research articles

DOI: 10.7897/2277-4343.1305127

Pages: 75-79

Author: A. Manisha, K. Naveen, A. Jyothi, Padmini Iriventi *

Abstract: The objective of the present study was to formulate and evaluate Topical gel containing Manjistha as a drug. A total of six gel formulations were prepared by homogenization technique using stearic acid, cholesterol, tween 80 and chloroform as excipients. Preformulation studies like UV spectrophotometry and FTIR were performed for the drug. Carbopol was used as a gelling agent in the preparation of these gels. Evaluation studies like pH, spreadability, viscosity, homogeneity and in vitro drug release studies were carried out. All the results were obtained to state that prepared gels have shown optimum results. Also, a gel containing stearic acid as a lipid (1:2) has shown maximum drug release compared to other gels.

Keyword: Manjistha, Cholesterol, Stearic acid, Topical gel.