Article: RANDOMIZED, SINGLE-BLIND, DOUBLE-ARM COMPARATIVE STUDY ON THE EFFECT OF ARJUNA (TERMINALIA ARJUNA ROXB) AND VITAMIN THERAPY (FOLIC ACID, B6, B12 IN COMBINATION) ON HOMOCYSTEINE

Article Category: Original Research articles

DOI: 10.7897/2277-4343.15376

Pages: 81-86

Author: Shubha V Hegde *

Abstract: Higher levels of homocysteine are strong indicators of susceptibility to CAD, PAD, myocardial infarction, stroke, metabolic disorders, nutritional deficiency, renal dysfunction and venous thromboembolism. All these disease conditions are studied under santarpana janya vyadhis in Ayurveda. Arjuna (Terminalia arjuna Roxb) has been indicated in text books of Ayurveda for Raktapitta, Arshas, Kushta, Prameha, Mutraghata and Vrana. It is also indicated in obesity, diseases of the urinary tract, cardiac disease and Kushta. Aim: Comparative study on the effect of Arjuna (Terminalia arjuna) and Vitamin therapy (Folic acid, B6, B12 in combination) in subjects with Homocysteine level >15 as a nutritional supplement. Methods: Randomized, single-blind, double-arm comparative study on Homocysteine levels more than 15 mm/lt are selected for IPD and OPD of SKAMCH&RC were administered 1 gm Arjuna tablets and vitamin tablets for three months, and Homocysteine levels were assessed before and after treatment. Results were evaluated by taking the difference between the baseline data and homocysteine level assessment data and analysed using the Students' paired t-test. Results indicate that Arjuna reduces homocysteine levels significantly and is comparable with Vitamin therapy.

Keyword: Homocysteine, Nutritional supplement, Santarpanajanya vyadhi