Article: ANTI CANCER EFFECT OF THE SIDDHA POLYHERBAL FORMULATION ASWATHY CHOORANAM AGAINST BRCA 1 GENE USING IN SILICO MODEL

Article Category: Original Research articles

DOI: 10.7897/2277-4343.154123

Pages: 84-88

Author: Bharathi NA *, Vetha Merlin Kumari H, Lakshmi Kantham T, Meena Kumari R

Abstract: India is one among the countries with enormous antiquity of health care practices. Siddha system is the pride of South India with alchemy and enormous spiritual insight in its root. Traditional medicines support primary health care needs of about 70% of Indian population. Cancer is the leading non communicable diseases with high mortality rates in which the abnormal cells divide uncontrollably with a potential to invade other parts of the body. Aswathy chooranam is a polyherbal drug with a potency to cure a wide range of diseases. The constituents are of hot potency and hence can be an effective choice to mitigate Kapha humour which is the main cause for formation of vippuruthi (tumour). The present study is performed in silico to evaluate the anti-cancerous potential of Siddha herbal formulation Aswathy chooranam through inhibition of BRCA 1 genes. Withaferin A, Glycyrrhizin, Gingerenone- A, Piperic acid, Piperine, Grandisin, Myristicin, Picroside I, β-caryophyllene and Vitexin in the formulation are found to have remarkable action against BRCA 1 genes. Compounds such as Withaferin A and Glycyrrhizin are well known for inducing apoptosis of cancer in vitro and in vivo and also in management of post chemotherapy management. Myristicin has potent inhibitory activities on cytokines, chemokines and nitric oxide. Piperine and piperic acid have been reported to have effective chemo preventive activities. The computational analysis shows effective binding against target Breast Cancer gene BRCA1. Hence Aswathy chooranam can be a promising choice for management and treatment of Breast Cancer.

Keyword: Breast Cancer, Siddha drug, Aswathy chooranam, Polyherbal drug, In silico