Article: A REVIEW ON TINOSPORA CORDIFOLIA AS A POTENTIAL ANTI-ANGIOGENIC AGENT IN A RANGE OF ANGIOGENIC DISEASES

Article Category: Review articles

DOI: 10.7897/2277-4343.16278

Pages: 234-241

Author: Pawar Amit Vikram *, Anil Kumar Middha, Basavraj Chivade

Abstract: Tinospora cordifolia (TC) has an impressive track record regarding its pharmacological potential in immunomodulatory, anti-inflammatory, and antioxidant activities in a range of diseases. The plant is acknowledged for having several other significant attributes. Angiogenesis plays a critical role in various developmental and pathological processes. TC is a significant medicinal important plant because of its variety of phytoconstituents including palmative, tinosporin, berberine, isocolumbin, and arabinogalactan, which play a critical role synergistically to tackle inflammation and oxidative stress, thus nominating itself as a potential anti-angiogenic agent in angiogenic diseases including cancer, rheumatoid arthritis, and psoriasis. Moreover, no significant adverse effects have been reported with its use. In this summary, author has reviewed the anti-angiogenic potential of TC, extrapolated TC’s mechanism of action from some angiogenic diseases to other possible angiogenic ailments, suggesting a plant origin has been identified as promising adjuncts or may be a dietary agent to the anti-angiogenic pharmacotherapies.

Keyword: Tinospora cordifolia, cancer, angiogenesis, neovascularization, and anti-angiogenic.