Article: EFFICACY AND SAFETY OF AN ANTI-HYPERTENSIVE HERBAL SYRUP IN PATIENTS WITH HYPERTENSION: A CLINICAL STUDY

Article Category: Original Research articles

DOI: 10.7897/2277-4343.165166

Pages: 40-45

Author: Ajay Kumar *, Prakash Raj Singh, Ranjit Singh, Tina Singhal

Abstract: Background: Hypertension is a major global health concern, often managed with synthetic drugs that may cause side effects. Herbal interventions offer a promising alternative. This study evaluated the efficacy and safety of an Anti-Hypertensive Herbal Syrup (AHS) formulated from Pyracantha crenulata fruit juice by DIBER (DRDO), Haldwani, Uttarakhand, India. Methods: A single-arm, open-label clinical trial was conducted with 50 hypertensive patients aged 20–60 years at Government Ayurvedic College and Hospital, Varanasi. Participants received 20 mL of AHS with 100 mL water twice daily for two months. Primary outcomes were changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP). Secondary outcomes included biochemical parameters and symptom relief. Data were analysed using Friedman’s test and Repeated Measures ANOVA. Results: Post-treatment, mean SBP decreased from 145 ± 12.31 mmHg to 123 ± 7.82 mmHg (p < 0.001), and DBP from 97.3 ± 7.35 mmHg to 79.6 ± 5.28 mmHg (p < 0.001). Stage-2 hypertension prevalence dropped from 68% to 6% (SBP) and 92% to 4% (DBP). Significant improvements were observed in lipid profile, haemoglobin, and symptom scores (p < 0.001). No adverse events were reported. Conclusions: AHS significantly reduced blood pressure and improved related biochemical parameters, suggesting its potential as a safe, effective herbal intervention for hypertension.

Keyword: Anti-Hypertensive Herbal Syrup, Pyracantha crenulate, hypertension, Ayurveda, Blood Pressure