Article: AN OPEN NON-RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF SIDDHA FORMULATION THOOTHUVALAI NEI IN THE MANAGEMENT OF SWASAKAASAM (BRONCHIAL ASTHMA)

Article Category: Original Research articles

DOI: 10.7897/2277-4343.165177

Pages: 99-106

Author: Deepthy VS *, Vetha Merlin Kumari H, Senthilvel G

Abstract: Background: Bronchial Asthma (Swasakaasam) is a widespread condition, and patients are visiting Ayothidoss Pandithar Hospital, National Institute of Siddha to manage this condition. Bronchial asthma is a heterogeneous pulmonary disorder characterized by recurrent episodes of cough, breathlessness and wheezing, which may resolve spontaneously or after the use of bronchodilator medication. This research article focuses on 10 cases of Bronchial Asthma (Swasakaasam) treated with Siddha Sastric herbal formulation Thoothuvalai Nei. Objective: To assess the therapeutic effectiveness of siddha formulation “Thoothuvalai nei” in the management of Swasakaasam patients by using Pulmonary function test, to observe the changes in clinical symptoms by Asthma control questionnaire and to evaluate the clinical lab parameters such as IgE, AEC, ESR before and after treatment. Methods: This clinical trial was conducted after getting IRRB and institutional Ethical Committee clearance (IEC NO.12/07/2023; NIS/24/IEC/2023/MP/41) and the clinical trial was also registered in CTRI (CTRI/2023/09/057541) Totally 25 patients were screened by using inclusion and exclusion criteria. Among these, the clinical trial was done in total 10 patients diagnosed as Swasakaasam within the age limit of 18-60 years. The trial drug Thoothuvalai nei 4ml with hot water, two times a day, after food were given once in 7 days for 48 days. The clinical improvement was documented by using Asthma control questionnaire. Results: FEV1(L) value, Serum IgE, AEC, ESR and Asthma control questionnaire before and after treatment were statistically analysed using Paired T test. There was a significant reduction in Serum IgE (P value-0.020), AEC (P value-0.002), ESR (P value-0.001) and Asthma control questionnaire (p value

Keyword: Swasakaasam, Bronchial Asthma, Thoothuvalai nei, Siddha formulation.